|
KMID : 0359720160340010045
|
|
Journal of the Korean Neurological Association
2016 Volume.34 No. 1 p.45 ~ p.48
|
|
|
Reversible Leukoencephlaopathy Caused by Doxifluridine in a Patient with Gastric Cancer
|
|
오성일:Oh Seong-Il
유영선:Ryu Young-Sun/김호숙:Kim Ho-Sook/신재국:Shin Jae-Gook/김상진:Kim Sang-Jin
|
|
|
Abstract
|
|
|
|
Doxifluridine neurotoxicity is more rare than 5-FU neurotoxicity. We report a case of leukoencephalopathy caused by long-term use of doxifluridine and which was resolved after discontinuation. A 37-year-old woman who had been on doxifluridine for 4 months after gastrectomy presented with dysarthria. Diffusion-weighted MRI imaging revealed multifocal hyperintense lesions in subcortical areas. Her symptoms disappeared after discontinuing doxifluridine, and lesions on follow-up MRI were resolved. These findings suggest that doxifluridine is a plausible cause of reversible leukoencephalopathy.
|
|
|
KEYWORD
|
|
|
Doxifluridine, Reversible leukoencephalopathy, Neurotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|